The history of microbiology begins with a Dutch haberdasher named Antoni van Leeuwenhoek, a man of no formal scientific education. In the late 1600s, Leeuwenhoek, inspired by the magnifying lenses used by drapers to examine cloth, assembled some of the first microscopes. He developed a technique for grinding and polishing tiny, convex lenses, some of which could magnify an object up to 270 times. After scraping some plaque from between his teeth and examining it under a lens, Leeuwenhoek found tiny squirming creatures, which he called “animalcules.” His observations, which he reported to the Royal Society of London, are among the first descriptions of living bacteria.
Leeuwenhoek discovered an entire universe invisible to the naked eye. He found more animalcules—protozoa and bacteria—in samples of pond water, rain water, and human saliva. He gave the first description of red corpuscles, observed plant tissue, examined muscle, and investigated the life cycle of insects.
Nearly two hundred years later, Leeuwenhoek’s discovery of microbes aided French chemist and biologist Louis Pasteur to develop his “germ theory of disease.” This concept suggested that disease derives from tiny organisms attacking and weakening the body. The germ theory later helped doctors to fight infectious diseases including anthrax, diphtheria, polio, smallpox, tetanus, and typhoid. Leeuwenhoek did not foresee this legacy. In a 1716 letter, he described his contribution to science this way: “My work, which I’ve done for a long time, was not pursued in order to gain the praise I now enjoy, but chiefly from a craving after knowledge, which I notice resides in me more than in most other men. And therewithal, whenever I found out anything remarkable, I have thought it my duty to put down my discovery on paper, so that all ingenious people might be informed thereof.”
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